PDO references polydioxanone. This is a synthetic, absorbable, monofilament suture that is safe to use in medical procedures. It has been used for cardiovascular and orthopedic surgery for more than a decade. Its main use has been for wound closure. Since it is dissolvable, when used as a suture it doesn’t need to be removed.
When used cosmetically, the threads are inserted in strategic locations and cause micro-injuries that the skin needs to heal. The healing process stimulates the production of collagen, elastin, and fibrin to heal the wound and this creates smoother and younger-looking skin. These also increase blood flow to the skin, giving it the nutrients it needs.